Leukotrienes are inflammatory chemicals produced by the body, specifically by white blood cells called leukocytes. They play a key role in the body's immune response, particularly in the lungs and in conditions like asthma and allergic reactions.
Key Points About Leukotrienes:
Functions
- Inflammatory Mediators: Leukotrienes contribute to the inflammation process by attracting immune cells to the site of infection or injury.
- Bronchoconstriction: In the lungs, leukotrienes can cause the muscles around the airways to tighten, leading to bronchoconstriction (narrowing of the airways), which is a hallmark of asthma.
- Increased Mucus Production: Leukotrienes also stimulate the production of mucus in the airways, which can further obstruct breathing.
Role in Asthma and Allergies:
- In asthma, leukotrienes are responsible for many of the symptoms, such as airway constriction, mucus production, and inflammation.
- In allergic reactions, leukotrienes can contribute to symptoms like swelling, itching, and hives
Leukotriene Modifiers:
- Medications such as Montelukast (Singulair), Zafirlukast (Accolate), and Zileuton (Zyflo) are classified as leukotriene receptor antagonists or leukotriene synthesis inhibitors. These drugs work by blocking the effects of leukotrienes, helping to reduce inflammation, bronchoconstriction, and mucus production.
- These medications are commonly used in the treatment of asthma and allergic rhinitis to help control symptoms and prevent asthma attacks.
Summary:
Leukotrienes are powerful inflammatory mediators involved in the pathophysiology of asthma, allergic reactions, and other inflammatory conditions. Medications that inhibit leukotrienes can be effective in managing and preventing symptoms associated with these conditions.
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