Regular eye exams are important for detecting and managing ocular complications, such as lens dislocation, in patients with Marfan syndrome.

Surgical repair or replacement of the aorta may be necessary to prevent complications such as aortic dissection or rupture in patients with significant aortic dilation.

Losartan is an angiotensin receptor blocker that decreases TGF-β signaling, which can further slow aortic dilation when used in combination with beta blockers.

Lisinopril, an ACE inhibitor, is used to slow aortic dilation and reduce cardiovascular complications in Marfan syndrome.

The diagnosis of Marfan syndrome is confirmed by identifying mutations in the FBN1 gene, which encodes the protein fibrillin-1.

Scoliosis, or an abnormal curvature of the spine, is common in Marfan syndrome and can contribute to the characteristic physical appearance.

Dislocation of the lens, or lens subluxation, is a common eye issue in Marfan syndrome due to weakened connective tissue.

Marfan syndrome commonly leads to aortic dilation and dissection due to the weakened connective tissue in the aorta, which is a significant cardiovascular risk

Individuals with Marfan syndrome often have a tall, slender build, with long arms and legs. This is a key clinical feature of the condition.

Marfan syndrome is inherited in an autosomal dominant pattern, meaning that one copy of the mutated FBN1 gene from either parent is sufficient to cause the disorder.